Protein Details: Neuronal acetylcholine receptor subunit alpha-5

Protein ID

ICDB_Pro_0900

Protein Name

Neuronal acetylcholine receptor subunit alpha-5

Gene Name

Chrna5

Organism

Mus musculus (Mouse)

Length

467 amino acids

AlphaFoldDB

AF-Q2MKA5-F1-model_v4.pdb

Function

After binding acetylcholine; the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.

Sequence

MAARGSRRRALRLLLMVQLLAGRWRPAGAARGARGGLPELSSAAKHEDSLFRDLFEDYEKWVRPVEHLSDKIKIKFGLAISQLVDVDEKNQLMTTNVWLKQEWIDVKLRWNPDDYGGIKIIRVPSDSLWIPDIVLFDNADGRFEGASTKTVVRYNGTVTWTQPANYKSSCTIDVTFFPFDLQNCSMKFGSWTYDGSQVDIILEDQDVDRTDFFDNGEWEIMSAMGSKGNRTDSCCWYPCITYSFVIKRLPLFYTLFLIIPCIGLSFLTVVVFYLPSNEGEKISLCTSVLVSLTVFLLVIEEIIPSSSKVIPLIGEYLVFTMIFVTLSIMVTVFAINIHHRSSSTHNAMAPWVRKIFLHKLPKLLCMRSHADRYFTQREEAEKDGGPKSRNTLEAALDCIRYITRHVVKENDVREVVEDWKFIAQVLDRMFLWTFLLVSIIGTLGLFVPVIYKWANIIVPVHIGNTIK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1007/bf02736842; 10.1038/ng1285; 10.1038/nature04406; 10.1101/gr.2596504; 10.1073/pnas.1602619113; 10.1086/506459; 10.1111/epi.12967

RefSeq

NP_000733.2 [Q15822-1]; NP_001269384.1 [Q15822-2]; XP_006716345.1; XP_011542690.1